Continuous directed evolution of aminoacyl-tRNA synthetases

Directed evolution of orthogonal aminoacyl-tRNA synthetases (AARSs) enables site-specific installation of non-canonical amino acids (ncAAs) into proteins. Traditional evolution techniques typically produce AARSs with greatly reduced activity and selectivity compared to their wild-type counterparts....

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Detalles Bibliográficos
Autores principales: Bryson, David I., Fan, Chenguang, Guo, Li-Tao, Miller, Corwin, Söll, Dieter, Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724969/
https://www.ncbi.nlm.nih.gov/pubmed/29035361
http://dx.doi.org/10.1038/nchembio.2474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724969/
https://www.ncbi.nlm.nih.gov/pubmed/29035361
http://dx.doi.org/10.1038/nchembio.2474

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