Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and γ-H2AX in colon cancer cells

Saikosaponin a (SSa), a bioactive phytochemical from Bupleurum, triggers sequential caspase-2 and caspase-8 activation, and thereby induces caspase-mediated apoptosis in human colon carcinoma (HCC) cells. However, the upstream mechanism of caspase-2 activation remains unknown. Therefore, we investig...

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Detalles Bibliográficos
Autores principales: Kang, Su Jin, Lee, Young Joon, Kang, Sung Gu, Cho, Soyoung, Yoon, Wonsuck, Lim, Ji Hong, Min, Sang-Hyun, Lee, Tae Ho, Kim, Byeong Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725032/
https://www.ncbi.nlm.nih.gov/pubmed/29245990
http://dx.doi.org/10.18632/oncotarget.22247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725032/
https://www.ncbi.nlm.nih.gov/pubmed/29245990
http://dx.doi.org/10.18632/oncotarget.22247

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