A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis

Neoplastic cells display reprogrammed metabolism due to the heightened energetic demands and the need for biomass synthesis of a growing tumor. Targeting metabolic vulnerabilities is thus an important goal for cancer therapy. Here, we describe a novel small-molecule arylsulfonamide (N-cyclobutyl-N-(...

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Detalles Bibliográficos
Autores principales: Dai, Xin, Kaluz, Stefan, Jiang, Ying, Shi, Lei, Mckinley, DeAngelo, Wang, Yingzhe, Wang, Binghe, Van Meir, Erwin G., Tan, Chalet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725089/
https://www.ncbi.nlm.nih.gov/pubmed/29245898
http://dx.doi.org/10.18632/oncotarget.22104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725089/
https://www.ncbi.nlm.nih.gov/pubmed/29245898
http://dx.doi.org/10.18632/oncotarget.22104

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