GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

Amyloidogenic processing of APP by β- and γ-secretases leads to the generation of amyloid-β peptide (Aβ), and the accumulation of Aβ in senile plaques is a hallmark of Alzheimer’s disease (AD). Understanding the mechanisms of APP processing is therefore paramount. Increasing evidence suggests that A...

Descripción completa

Detalles Bibliográficos
Autores principales: Vivien Chiu, Wai Yin, Koon, Alex Chun, Ki Ngo, Jacky Chi, Edwin Chan, Ho Yin, Lau, Kwok-Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget(Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725091/
https://www.ncbi.nlm.nih.gov/pubmed/29245900
http://dx.doi.org/10.18632/oncotarget.20062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725091/
https://www.ncbi.nlm.nih.gov/pubmed/29245900
http://dx.doi.org/10.18632/oncotarget.20062

Ejemplares similares