Cargando…

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

Amyloidogenic processing of APP by β- and γ-secretases leads to the generation of amyloid-β peptide (Aβ), and the accumulation of Aβ in senile plaques is a hallmark of Alzheimer’s disease (AD). Understanding the mechanisms of APP processing is therefore paramount. Increasing evidence suggests that A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vivien Chiu, Wai Yin, Koon, Alex Chun, Ki Ngo, Jacky Chi, Edwin Chan, Ho Yin, Lau, Kwok-Fai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper: Gerotarget(Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725091/ https://www.ncbi.nlm.nih.gov/pubmed/29245900 http://dx.doi.org/10.18632/oncotarget.20062

Ejemplares similares

Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression
por: Kong, Yan, et al.
Publicado: (2016)

Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1
por: Nelson, Vinod K., et al.
Publicado: (2016)

Prostaglandin I(2) is responsible for ameliorating prostaglandin E(2) stress in stimulating the expression of tumor necrosis factor α in a β-amyloid protein -dependent mechanism
por: Zheng, Shao-Qin, et al.
Publicado: (2017)

Royal jelly promotes DAF-16-mediated proteostasis to tolerate β-amyloid toxicity in C. elegans model of Alzheimer's disease
por: Wang, Xiaoxia, et al.
Publicado: (2016)

Anticoagulants inhibit proteolytic clearance of plasma amyloid beta
por: Yang, Lu, et al.
Publicado: (2017)

Rapamycin preserves gut homeostasis during Drosophila aging
por: Fan, Xiaolan, et al.
Publicado: (2015)

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity
por: Danilov, Anton, et al.
Publicado: (2015)

Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats
por: Stefanova, Natalia A., et al.
Publicado: (2014)

E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion
por: Benvegnù, Stefano, et al.
Publicado: (2017)

Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis
por: Chen, Jingnan, et al.
Publicado: (2016)

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling
por: Wang, Gang, et al.
Publicado: (2016)

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster
por: Wagner, Anika E., et al.
Publicado: (2015)

Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy
por: Bosch-Morató, Mònica, et al.
Publicado: (2016)

β-Hydroxybutyrate suppresses inflammasome formation by ameliorating endoplasmic reticulum stress via AMPK activation
por: Bae, Ha Ram, et al.
Publicado: (2016)

Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats
por: Xia, Zhiming, et al.
Publicado: (2017)

Drosophila PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway
por: Pyo, Jung-Hoon, et al.
Publicado: (2018)

Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing
por: Hu, Tao, et al.
Publicado: (2017)

Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology
por: Chaput, Dale, et al.
Publicado: (2016)

A Study to Investigate the Role of GULP/ CED 6 Gene in “Eat Me” Signaling in Cellular Efferocytosis and Immunosurveillance
por: Banerjee, H, et al.
Publicado: (2016)

Azilsartan ameliorates apoptosis of dopaminergic neurons and rescues characteristic parkinsonian behaviors in a rat model of Parkinson’s disease
por: Gao, Qing, et al.
Publicado: (2017)

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease
por: Lesuis, Sylvie L., et al.
Publicado: (2016)

SS31 Ameliorates age-related activation of NF-κB signaling in senile mice model, SAMP8
por: Hao, Zhi-Hua, et al.
Publicado: (2016)

Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model
por: Iwata, Yuko, et al.
Publicado: (2018)

Endurance exercise prevents high-fat-diet induced heart and mobility premature aging and dsir2 expression decline in aging Drosophila
por: Wen, Deng-Tai, et al.
Publicado: (2017)

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT(1A) receptor mediated Akt/GSK-3β pathway
por: Wang, Yan-Juan, et al.
Publicado: (2016)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

Identification of cardiac-related circulating microRNA profile in human chronic heart failure
por: Li, Huaping, et al.
Publicado: (2015)

How does white matter microstructure differ between the vascular and amnestic mild cognitive impairment?
por: Yu, Yang, et al.
Publicado: (2016)

Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease
por: Chiu, Ching-Chi, et al.
Publicado: (2016)

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1
por: Wu, Bing, et al.
Publicado: (2016)

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence
por: Zhang, Jia-an, et al.
Publicado: (2016)

Impact of SORL1 genetic variations on MRI markers in non-demented elders
por: Yin, Rui-Hua, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l11461cfi14skoand2spimqalg