Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells

We hypothesized that aldehyde dehydrogenase1 (ALDH1) protects cancer cells from retinaldehyde-induced cytotoxicity, and that targeting this enzyme would enhance the therapeutic effect of retinaldehyde. ALDEFLUOR™ assays showed high ALDH activity in A549 and H522 cancer cells and low activity in H166...

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Detalles Bibliográficos
Autores principales: Park, Jin Won, Jung, Kyung-Ho, Lee, Jin Hee, Moon, Seung Hwan, Cho, Young Seok, Lee, Kyung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725100/
https://www.ncbi.nlm.nih.gov/pubmed/29245909
http://dx.doi.org/10.18632/oncotarget.19544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725100/
https://www.ncbi.nlm.nih.gov/pubmed/29245909
http://dx.doi.org/10.18632/oncotarget.19544

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