Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest

Cisplatin (CDDP) and its derivatives are first line anti-cancer drugs for ovarian cancer (OVCA). However, chemoresistance due to high incidence of p53 mutations leads to poor clinical prognosis. Saikosaponin-d (Ssd), a saponin from a herbal plant extract, has been shown to induce cell death and sens...

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Detalles Bibliográficos
Autores principales: Tsuyoshi, Hideaki, Wong, Vincent Kam Wai, Han, Yu, Orisaka, Makoto, Yoshida, Yoshio, Tsang, Benjamin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725134/
https://www.ncbi.nlm.nih.gov/pubmed/29245943
http://dx.doi.org/10.18632/oncotarget.21076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725134/
https://www.ncbi.nlm.nih.gov/pubmed/29245943
http://dx.doi.org/10.18632/oncotarget.21076

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