Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs

Drug-induced liver injury (DILI) presents a significant challenge to drug development and regulatory science. The FDA’s Liver Toxicity Knowledge Base (LTKB) evaluated >1000 drugs for their likelihood of causing DILI in humans, of which >700 drugs were classified into three categories (most-DIL...

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Detalles Bibliográficos
Autores principales: Hong, Huixiao, Thakkar, Shraddha, Chen, Minjun, Tong, Weida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725422/
https://www.ncbi.nlm.nih.gov/pubmed/29229971
http://dx.doi.org/10.1038/s41598-017-17701-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725422/
https://www.ncbi.nlm.nih.gov/pubmed/29229971
http://dx.doi.org/10.1038/s41598-017-17701-7

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