Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b

Prompted by earlier findings that the Rac1-related isoform Rac1b inhibits transforming growth factor (TGF)-β1-induced canonical Smad signalling, we studied here whether Rac1b also impacts TGF-β1-dependent non-Smad signalling such as the MKK6-p38 and MEK-ERK mitogen-activated protein kinase (MAPK) pa...

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Detalles Bibliográficos
Autores principales: Witte, David, Otterbein, Hannah, Förster, Maria, Giehl, Klaudia, Zeiser, Robert, Lehnert, Hendrik, Ungefroren, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725500/
https://www.ncbi.nlm.nih.gov/pubmed/29229918
http://dx.doi.org/10.1038/s41598-017-15170-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725500/
https://www.ncbi.nlm.nih.gov/pubmed/29229918
http://dx.doi.org/10.1038/s41598-017-15170-6

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