Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV

Fingolimod (FTY720), a structural analogue of sphingosine, targets sphingosine-1-phosphate receptor signaling and is currently an immunomodulatory therapy for multiple sclerosis. Fingolimod accesses the central nervous system (CNS) where its active metabolite, fingolimod phosphate (FTY720-P), has pl...

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Detalles Bibliográficos
Autores principales: Geffin, Rebeca, Martinez, Ricardo, de las Pozas, Alicia, Issac, Biju, McCarthy, Micheline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725524/
https://www.ncbi.nlm.nih.gov/pubmed/28913617
http://dx.doi.org/10.1007/s13365-017-0571-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725524/
https://www.ncbi.nlm.nih.gov/pubmed/28913617
http://dx.doi.org/10.1007/s13365-017-0571-7

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