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Three-dimensional Modelling of the Voltage-gated Sodium Ion Channel from Anopheles gambiae Reveals Spatial Clustering of Evolutionarily Conserved Acidic Residues at the Extracellular Sites

BACKGROUND: The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS: A homology model of the transmembrane and extracellular r...

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Detalles Bibliográficos
Autores principales: Vinekar, Rithvik S., Sowdhamini, Ramanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725538/
https://www.ncbi.nlm.nih.gov/pubmed/27919210
http://dx.doi.org/10.2174/1567201814666161205131213