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Three-dimensional Modelling of the Voltage-gated Sodium Ion Channel from Anopheles gambiae Reveals Spatial Clustering of Evolutionarily Conserved Acidic Residues at the Extracellular Sites
BACKGROUND: The eukaryotic voltage-gated sodium channel(e-Nav) is a large asymmetric transmembrane protein with important functions concerning neurological function. No structure has been resolved at high resolution for this protein. METHODS: A homology model of the transmembrane and extracellular r...
Autores principales: | Vinekar, Rithvik S., Sowdhamini, Ramanathan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725538/ https://www.ncbi.nlm.nih.gov/pubmed/27919210 http://dx.doi.org/10.2174/1567201814666161205131213 |
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