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Opioids and the Blood-Brain Barrier: A Dynamic Interaction with  Consequences on Drug Disposition in Brain

BACKGROUND: Opioids are widely used in pain management, acting via opioid receptors and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood-brain barrier (BBB), several influx and efflux transporters, such as the ATP-binding cassette (ABC) P-glycoprotein (P-gp, ABC...

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Detalles Bibliográficos
Autores principales:	Chaves, Catarina, Remião, Fernando, Cisternino, Salvatore, Declèves, Xavier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725546/ https://www.ncbi.nlm.nih.gov/pubmed/28474563 http://dx.doi.org/10.2174/1570159X15666170504095823

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