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Proteomics and Network Analyses Reveal Inhibition of Akt‐mTOR Signaling in CD4(+) T Cells by Mycobacterium tuberculosis Mannose‐Capped Lipoarabinomannan
Mycobacterium tuberculosis (Mtb) cell wall glycolipid mannose‐capped lipoarabinomannan (ManLAM) inhibits CD4(+) T‐cell activation by inhibiting proximal T‐cell receptor (TCR) signaling when activated by anti‐CD3. To understand the impact of ManLAM on CD4(+) T‐cell function when both the TCR–CD3 comp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725663/ https://www.ncbi.nlm.nih.gov/pubmed/28994205 http://dx.doi.org/10.1002/pmic.201700233 |