Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA – effects on NS5B catalysis and allosteric inhibition

BACKGROUND: Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carcinoma (HCC), for which the mechanism remains obscure and th...

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Detalles Bibliográficos
Autores principales: Solbak, Sara M. Ø., Abdurakhmanov, Eldar, Vedeler, Anni, Danielson, U. Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725786/
https://www.ncbi.nlm.nih.gov/pubmed/29228983
http://dx.doi.org/10.1186/s12985-017-0904-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725786/
https://www.ncbi.nlm.nih.gov/pubmed/29228983
http://dx.doi.org/10.1186/s12985-017-0904-4

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