Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

The spontaneous deamination of cytosine is a major source of C•G to T•A transitions, which account for half of known human pathogenic point mutations. The ability to efficiently convert target A•T base pairs to G•C therefore could advance the study and treatment of genetic diseases. While the deamin...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaudelli, Nicole M., Komor, Alexis C., Rees, Holly A., Packer, Michael S., Badran, Ahmed H., Bryson, David I., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726555/
https://www.ncbi.nlm.nih.gov/pubmed/29160308
http://dx.doi.org/10.1038/nature24644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726555/
https://www.ncbi.nlm.nih.gov/pubmed/29160308
http://dx.doi.org/10.1038/nature24644

Ejemplares similares