Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map

The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to systematically assess the prevalence and consequence...

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Detalles Bibliográficos
Autores principales: Smith, Ian, Greenside, Peyton G., Natoli, Ted, Lahr, David L., Wadden, David, Tirosh, Itay, Narayan, Rajiv, Root, David E., Golub, Todd R., Subramanian, Aravind, Doench, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726721/
https://www.ncbi.nlm.nih.gov/pubmed/29190685
http://dx.doi.org/10.1371/journal.pbio.2003213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726721/
https://www.ncbi.nlm.nih.gov/pubmed/29190685
http://dx.doi.org/10.1371/journal.pbio.2003213

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