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Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to systematically assess the prevalence and consequence...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726721/ https://www.ncbi.nlm.nih.gov/pubmed/29190685 http://dx.doi.org/10.1371/journal.pbio.2003213 |