Monobactam formation in sulfazecin by a non-ribosomal peptide synthetase thioesterase

The N-sulfonated monocyclic β-lactam ring characteristic of the monobactams confers resistance to zinc metallo-β-lactamases and affords the most effective class to combat carbapenem-resistant enterobacteria (CRE). Here we report unprecedented non-ribosomal peptide synthetase activities where an asse...

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Detalles Bibliográficos
Autores principales: Oliver, Ryan A., Li, Rongfeng, Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726899/
https://www.ncbi.nlm.nih.gov/pubmed/29155429
http://dx.doi.org/10.1038/nchembio.2526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726899/
https://www.ncbi.nlm.nih.gov/pubmed/29155429
http://dx.doi.org/10.1038/nchembio.2526

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