Small-molecule inhibition of TLR8 through stabilization of its resting state

Endosomal Toll-like receptors (TLR3/7/8/9) are highly analogous sensors for various viral or bacterial RNA/DNA molecular patterns. Nonetheless, few small-molecules can selectively modulate these TLRs. In this manuscript, we identified the first human TLR8-specific small-molecule antagonists via a no...

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Detalles Bibliográficos
Autores principales: Zhang, Shuting, Hu, Zhenyi, Tanji, Hiromi, Jiang, Shuangshuang, Das, Nabanita, Li, Jing, Sakaniwa, Kentaro, Jin, Jin, Bian, Yanyan, Ohto, Umeharu, Shimizu, Toshiyuki, Yin, Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726935/
https://www.ncbi.nlm.nih.gov/pubmed/29155428
http://dx.doi.org/10.1038/nchembio.2518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726935/
https://www.ncbi.nlm.nih.gov/pubmed/29155428
http://dx.doi.org/10.1038/nchembio.2518

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