Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B

The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer. Previous structural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed active site, and rearrangem...

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Detalles Bibliográficos
Autores principales: Shi, Ke, Demir, Özlem, Carpenter, Michael A., Wagner, Jeff, Kurahashi, Kayo, Harris, Reuben S., Amaro, Rommie E., Aihara, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727031/
https://www.ncbi.nlm.nih.gov/pubmed/29234087
http://dx.doi.org/10.1038/s41598-017-17694-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727031/
https://www.ncbi.nlm.nih.gov/pubmed/29234087
http://dx.doi.org/10.1038/s41598-017-17694-3

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