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Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B
The APOBEC3B (A3B) single-stranded DNA (ssDNA) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of mutations in cancer. Previous structural studies showed that the C-terminal catalytic domain of human A3B has a tightly closed active site, and rearrangem...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727031/ https://www.ncbi.nlm.nih.gov/pubmed/29234087 http://dx.doi.org/10.1038/s41598-017-17694-3 |