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PEPD is a pivotal regulator of p53 tumor suppressor

p53 tumor suppressor responds to various cellular stresses and regulates cell fate. Here, we show that peptidase D (PEPD) binds and suppresses over half of nuclear and cytoplasmic p53 under normal conditions, independent of its enzymatic activity. Eliminating PEPD causes cell death and tumor regress...

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Detalles Bibliográficos
Autores principales: Yang, Lu, Li, Yun, Bhattacharya, Arup, Zhang, Yuesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727116/
https://www.ncbi.nlm.nih.gov/pubmed/29233996
http://dx.doi.org/10.1038/s41467-017-02097-9