Mechanistic Insights into the Reaction of Chlorination of Tryptophan Catalyzed by Tryptophan 7-Halogenase

Tryptophan 7-halogenase catalyzes chlorination of free tryptophan to 7-chlorotryptophan, which is the first step in the antibiotic pyrrolnitrin biosynthesis. Many biologically and pharmaceutically active natural products contain chlorine and thus, an understanding of the mechanism of its introductio...

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Detalles Bibliográficos
Autores principales: Karabencheva-Christova, Tatyana G., Torras, Juan, Mulholland, Adrian J., Lodola, Alessio, Christov, Christo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727139/
https://www.ncbi.nlm.nih.gov/pubmed/29234124
http://dx.doi.org/10.1038/s41598-017-17789-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727139/
https://www.ncbi.nlm.nih.gov/pubmed/29234124
http://dx.doi.org/10.1038/s41598-017-17789-x

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