Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate

Complex molecular responses preserve gene expression accuracy and genome integrity in the face of environmental perturbations. Here we report that, in response to UV irradiation, RNA polymerase II (RNAPII) molecules are dynamically and synchronously released from promoter-proximal regions into elong...

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Detalles Bibliográficos
Autores principales: Lavigne, Matthieu D., Konstantopoulos, Dimitris, Ntakou-Zamplara, Katerina Z., Liakos, Anastasios, Fousteri, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727188/
https://www.ncbi.nlm.nih.gov/pubmed/29233992
http://dx.doi.org/10.1038/s41467-017-02145-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727188/
https://www.ncbi.nlm.nih.gov/pubmed/29233992
http://dx.doi.org/10.1038/s41467-017-02145-4

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