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Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate
Complex molecular responses preserve gene expression accuracy and genome integrity in the face of environmental perturbations. Here we report that, in response to UV irradiation, RNA polymerase II (RNAPII) molecules are dynamically and synchronously released from promoter-proximal regions into elong...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727188/ https://www.ncbi.nlm.nih.gov/pubmed/29233992 http://dx.doi.org/10.1038/s41467-017-02145-4 |