Development of Erasin: a chromone-based STAT3 inhibitor which induces apoptosis in Erlotinib-resistant lung cancer cells

Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications of a chr...

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Detalles Bibliográficos
Autores principales: Lis, Christian, Rubner, Stefan, Roatsch, Martin, Berg, Angela, Gilcrest, Tyler, Fu, Darwin, Nguyen, Elizabeth, Schmidt, Anne-Marie, Krautscheid, Harald, Meiler, Jens, Berg, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727211/
https://www.ncbi.nlm.nih.gov/pubmed/29234062
http://dx.doi.org/10.1038/s41598-017-17600-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727211/
https://www.ncbi.nlm.nih.gov/pubmed/29234062
http://dx.doi.org/10.1038/s41598-017-17600-x

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