Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout

CD38 is an ectoenzyme and receptor with key physiological roles. It metabolizes NAD(+) to adenosine diphosphate ribose (ADPR) and cyclic ADPR, regulating several processes including calcium signalling. CD38 is both a positive and negative prognostic indicator in leukaemia. In all-trans retinoic acid...

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Detalles Bibliográficos
Autores principales: MacDonald, Robert J., Shrimp, Jonathan H., Jiang, Hong, Zhang, Lu, Lin, Hening, Yen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727258/
https://www.ncbi.nlm.nih.gov/pubmed/29234114
http://dx.doi.org/10.1038/s41598-017-17720-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727258/
https://www.ncbi.nlm.nih.gov/pubmed/29234114
http://dx.doi.org/10.1038/s41598-017-17720-4

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