The Sam-Sam interaction between Ship2 and the EphA2 receptor: design and analysis of peptide inhibitors

The lipid phosphatase Ship2 represents a drug discovery target for the treatment of different diseases, including cancer. Its C-terminal sterile alpha motif domain (Ship2-Sam) associates with the Sam domain from the EphA2 receptor (EphA2-Sam). This interaction is expected to mainly induce pro-oncoge...

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Detalles Bibliográficos
Autores principales: Mercurio, Flavia Anna, Di Natale, Concetta, Pirone, Luciano, Iannitti, Roberta, Marasco, Daniela, Pedone, Emilia Maria, Palumbo, Rosanna, Leone, Marilisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727260/
https://www.ncbi.nlm.nih.gov/pubmed/29234063
http://dx.doi.org/10.1038/s41598-017-17684-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727260/
https://www.ncbi.nlm.nih.gov/pubmed/29234063
http://dx.doi.org/10.1038/s41598-017-17684-5

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