Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice with metastasis as readout and identify OTUD1 as a metastasis-repressing factor. OTUD1-silenced cancer cells show mesenchymal and stem-cell-l...

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Detalles Bibliográficos
Autores principales: Zhang, Zhengkui, Fan, Yao, Xie, Feng, Zhou, Hang, Jin, Ke, Shao, Li, Shi, Wenhao, Fang, Pengfei, Yang, Bing, van Dam, Hans, ten Dijke, Peter, Zheng, Xiaofeng, Yan, Xiaohua, Jia, Junling, Zheng, Min, Jin, Jin, Ding, Chen, Ye, Sheng, Zhou, Fangfang, Zhang, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727433/
https://www.ncbi.nlm.nih.gov/pubmed/29235476
http://dx.doi.org/10.1038/s41467-017-02029-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727433/
https://www.ncbi.nlm.nih.gov/pubmed/29235476
http://dx.doi.org/10.1038/s41467-017-02029-7

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