Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors

The catalytically dead Cpf1 endonuclease from Acidaminococcus sp. BV3L6 (dAsCpf1) has been used to construct effective transcriptional repressors in bacteria and plants. However, it is still unclear if dAsCpf1 can function in human cells as a transcriptional regulator or a signal conductor. Here, we...

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Detalles Bibliográficos
Autores principales: Liu, Yuchen, Han, Jinghong, Chen, Zhicong, Wu, Hanwei, Dong, Hongsong, Nie, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727435/
https://www.ncbi.nlm.nih.gov/pubmed/29235474
http://dx.doi.org/10.1038/s41467-017-02265-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727435/
https://www.ncbi.nlm.nih.gov/pubmed/29235474
http://dx.doi.org/10.1038/s41467-017-02265-x

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