Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

[Image: see text] The phenoxy alkyl benzimidazoles (PABs) have good antitubercular activity. We expanded our structure–activity relationship studies to determine the core components of PABs required for activity. The most potent compounds had minimum inhibitory concentrations against Mycobacterium t...

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Detalles Bibliográficos
Autores principales: Chandrasekera, N. Susantha, Berube, Bryan J., Shetye, Gauri, Chettiar, Somsundaram, O’Malley, Theresa, Manning, Alyssa, Flint, Lindsay, Awasthi, Divya, Ioerger, Thomas R., Sacchettini, James, Masquelin, Thierry, Hipskind, Philip A., Odingo, Joshua, Parish, Tanya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727484/
https://www.ncbi.nlm.nih.gov/pubmed/29035551
http://dx.doi.org/10.1021/acsinfecdis.7b00112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727484/
https://www.ncbi.nlm.nih.gov/pubmed/29035551
http://dx.doi.org/10.1021/acsinfecdis.7b00112

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