The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone

The mechanisms hallmarking melanoma progression are insufficiently understood. Here we studied the impact of the unfolded protein response (UPR) - a signalling cascade playing ambiguous roles in carcinogenesis - in melanoma malignancy. We identified isogenic patient-derived melanoma cell lines harbo...

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Detalles Bibliográficos
Autores principales: Eigner, Karin, Filik, Yüksel, Mark, Florian, Schütz, Birgit, Klambauer, Günter, Moriggl, Richard, Hengstschläger, Markus, Stangl, Herbert, Mikula, Mario, Röhrl, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727496/
https://www.ncbi.nlm.nih.gov/pubmed/29235576
http://dx.doi.org/10.1038/s41598-017-17888-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727496/
https://www.ncbi.nlm.nih.gov/pubmed/29235576
http://dx.doi.org/10.1038/s41598-017-17888-9

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