A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway

The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the interm...

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Detalles Bibliográficos
Autores principales: Vandyshev, Dmitry Yu, Shikhaliev, Khidmet S, Potapov, Andrey Yu, Krysin, Michael Yu, Zubkov, Fedor I, Sapronova, Lyudmila V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727784/
https://www.ncbi.nlm.nih.gov/pubmed/29259665
http://dx.doi.org/10.3762/bjoc.13.252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727784/
https://www.ncbi.nlm.nih.gov/pubmed/29259665
http://dx.doi.org/10.3762/bjoc.13.252

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