Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High‐Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures

BACKGROUND. Pediatric brain tumors are the leading cause of death for children with cancer in the U.S. Incorporating next‐generation sequencing data for both pediatric low‐grade (pLGGs) and high‐grade gliomas (pHGGs) can inform diagnostic, prognostic, and therapeutic decision‐making. MATERIALS AND M...

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Detalles Bibliográficos
Autores principales: Johnson, Adrienne, Severson, Eric, Gay, Laurie, Vergilio, Jo‐Anne, Elvin, Julia, Suh, James, Daniel, Sugganth, Covert, Mandy, Frampton, Garrett M., Hsu, Sigmund, Lesser, Glenn J., Stogner‐Underwood, Kimberly, Mott, Ryan T., Rush, Sarah Z., Stanke, Jennifer J., Dahiya, Sonika, Sun, James, Reddy, Prasanth, Chalmers, Zachary R., Erlich, Rachel, Chudnovsky, Yakov, Fabrizio, David, Schrock, Alexa B., Ali, Siraj, Miller, Vincent, Stephens, Philip J., Ross, Jeffrey, Crawford, John R., Ramkissoon, Shakti H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2017
Materias:
Neuro‐Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728033/
https://www.ncbi.nlm.nih.gov/pubmed/28912153
http://dx.doi.org/10.1634/theoncologist.2017-0242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728033/
https://www.ncbi.nlm.nih.gov/pubmed/28912153
http://dx.doi.org/10.1634/theoncologist.2017-0242

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