Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

All DNA polymerases misincorporate ribonucleotides despite their preference for deoxyribonucleotides, and analysis of cultured cells indicates that mammalian mitochondrial DNA (mtDNA) tolerates such replication errors. However, it is not clear to what extent misincorporation occurs in tissues, or wh...

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Detalles Bibliográficos
Autores principales: Moss, Chloe F., Dalla Rosa, Ilaria, Hunt, Lilian E., Yasukawa, Takehiro, Young, Robert, Jones, Aleck W. E., Reddy, Kaalak, Desai, Radha, Virtue, Sam, Elgar, Greg, Voshol, Peter, Taylor, Martin S., Holt, Ian J., Reijns, Martin A. M., Spinazzola, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728394/
https://www.ncbi.nlm.nih.gov/pubmed/29106596
http://dx.doi.org/10.1093/nar/gkx1009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728394/
https://www.ncbi.nlm.nih.gov/pubmed/29106596
http://dx.doi.org/10.1093/nar/gkx1009

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