Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase

Fungal tRNA ligase (Trl1) is an essential enzyme that repairs RNA breaks with 2′,3′-cyclic-PO(4) and 5′-OH ends inflicted during tRNA splicing and non-canonical mRNA splicing in the fungal unfolded protein response. Trl1 is composed of C-terminal cyclic phosphodiesterase and central polynucleotide k...

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Detalles Bibliográficos
Autores principales: Remus, Barbara S., Goldgur, Yehuda, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728400/
https://www.ncbi.nlm.nih.gov/pubmed/29165709
http://dx.doi.org/10.1093/nar/gkx1159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728400/
https://www.ncbi.nlm.nih.gov/pubmed/29165709
http://dx.doi.org/10.1093/nar/gkx1159

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