PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

PARP1-dependent poly-ADP-ribosylation (PARylation) participates in the repair of many forms of DNA damage. Here, we used atomic force microscopy (AFM) and single molecule fluorescence microscopy to examine the interactions of PARP1 with common DNA repair intermediates. AFM volume analysis indicates...

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Detalles Bibliográficos
Autores principales: Liu, Lili, Kong, Muwen, Gassman, Natalie R., Freudenthal, Bret D., Prasad, Rajendra, Zhen, Stephanie, Watkins, Simon C., Wilson, Samuel H., Van Houten, Bennett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728402/
https://www.ncbi.nlm.nih.gov/pubmed/29121337
http://dx.doi.org/10.1093/nar/gkx1047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728402/
https://www.ncbi.nlm.nih.gov/pubmed/29121337
http://dx.doi.org/10.1093/nar/gkx1047

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