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Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation

A bacterial translation factor EF-P alleviates ribosomal stalling caused by polyproline sequence by accelerating Pro-Pro formation. EF-P recognizes a specific D-arm motif found in tRNA(Pro) isoacceptors, 9-nt D-loop closed by a stable D-stem sequence, for Pro-selective peptidyl-transfer acceleration...

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Detalles Bibliográficos
Autores principales: Katoh, Takayuki, Iwane, Yoshihiko, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728406/
https://www.ncbi.nlm.nih.gov/pubmed/29155943
http://dx.doi.org/10.1093/nar/gkx1129