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Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine
BACKGROUND: Ranitidine (Zantac(®)) is a H(2)-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly genetically variable. Twelve...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728534/ https://www.ncbi.nlm.nih.gov/pubmed/29236753 http://dx.doi.org/10.1371/journal.pone.0189521 |