Mechanism of tandem duplication formation in BRCA1 mutant cells

Small ~10 kb microhomology-mediated tandem duplications (“Group 1 TDs”) are abundant in BRCA1-linked but not BRCA2-linked breast cancer genomes. Here, we define the mechanism underlying this “rearrangement signature”. We show that BRCA1, but not BRCA2, suppresses TDs at a Tus/Ter site-specific chrom...

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Detalles Bibliográficos
Autores principales: Willis, Nicholas A., Frock, Richard L., Menghi, Francesca, Duffey, Erin E., Panday, Arvind, Camacho, Virginia, Hasty, E. Paul, Liu, Edison T., Alt, Frederick W., Scully, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728692/
https://www.ncbi.nlm.nih.gov/pubmed/29168504
http://dx.doi.org/10.1038/nature24477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728692/
https://www.ncbi.nlm.nih.gov/pubmed/29168504
http://dx.doi.org/10.1038/nature24477

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