Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways

Long non-coding RNAs (lncRNAs) play a pivotal role in tumorigenesis, exemplified by the recent finding that lncRNA maternally expressed gene 3 (MEG3) inhibits tumor growth in a p53-dependent manner. Acute myeloid leukemia (AML) is the most common malignant myeloid disorder in adults, and TP53 mutati...

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Detalles Bibliográficos
Autores principales: Lyu, Y, Lou, J, Yang, Y, Feng, J, Hao, Y, Huang, S, Yin, L, Xu, J, Huang, D, Ma, B, Zou, D, Wang, Y, Zhang, Y, Zhang, B, Chen, P, Yu, K, Lam, E W-F, Wang, X, Liu, Q, Yan, J, Jin, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729340/
https://www.ncbi.nlm.nih.gov/pubmed/28400619
http://dx.doi.org/10.1038/leu.2017.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729340/
https://www.ncbi.nlm.nih.gov/pubmed/28400619
http://dx.doi.org/10.1038/leu.2017.116

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