Cargando…
Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy
This study explores the regulation and importance of System L amino acid transport in a murine model of T-cell acute lymphoblastic leukemia (T-ALL) caused by deletion of phosphatase and tensin homolog deleted on chromosome 10 (PTEN). There has been a strong focus on glucose transport in leukemias bu...
Autores principales: | Grzes, K M, Swamy, M, Hukelmann, J L, Emslie, E, Sinclair, L V, Cantrell, D A |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729345/ https://www.ncbi.nlm.nih.gov/pubmed/28546582 http://dx.doi.org/10.1038/leu.2017.160 |
Ejemplares similares
-
Antigen receptor control of amino acid transport coordinates the metabolic re-programming that is essential for T cell differentiation
por: Sinclair, Linda V., et al.
Publicado: (2013) -
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
por: Swamy, Mahima, et al.
Publicado: (2016) -
Single cell analysis of kynurenine and System L amino acid transport in T cells
por: Sinclair, Linda V., et al.
Publicado: (2018) -
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
por: Loftus, Róisín M., et al.
Publicado: (2018) -
The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin
por: Hukelmann, Jens L., et al.
Publicado: (2015)