Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase

The methylation of natural products by S-adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in many biosynthetic pathways. The introduction of methyl substituents can affect the biological and physicochemical properties of the secondary met...

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Detalles Bibliográficos
Autores principales: Law, Brian J. C., Struck, Anna-Winona, Bennett, Matthew R., Wilkinson, Barrie, Micklefield, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729408/
https://www.ncbi.nlm.nih.gov/pubmed/29403635
http://dx.doi.org/10.1039/c5sc00164a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729408/
https://www.ncbi.nlm.nih.gov/pubmed/29403635
http://dx.doi.org/10.1039/c5sc00164a

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