Cargando…

Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase

The methylation of natural products by S-adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in many biosynthetic pathways. The introduction of methyl substituents can affect the biological and physicochemical properties of the secondary met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Law, Brian J. C., Struck, Anna-Winona, Bennett, Matthew R., Wilkinson, Barrie, Micklefield, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729408/ https://www.ncbi.nlm.nih.gov/pubmed/29403635 http://dx.doi.org/10.1039/c5sc00164a

Ejemplares similares

Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways
por: Herbert, Abigail J., et al.
Publicado: (2020)

Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase
por: Law, Brian J. C., et al.
Publicado: (2016)

Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29
por: Wu, Ming-Cheng, et al.
Publicado: (2015)

Engineering enzymatic assembly lines to produce new antibiotics
por: Bozhüyük, Kenan AJ, et al.
Publicado: (2019)

A Structure‐Guided Switch in the Regioselectivity of a Tryptophan Halogenase
por: Shepherd, Sarah A., et al.
Publicado: (2016)

Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase
por: Bennett, Matthew R., et al.
Publicado: (2018)

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes
por: Shepherd, Sarah A., et al.
Publicado: (2015)

Signaling Mechanisms that Suppress the Cytostatic Actions of Rapamycin
por: Jahn, Stephan C., et al.
Publicado: (2014)

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase
por: Czarnota, Sylwia, et al.
Publicado: (2019)

Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel
por: Zhang, Jingyao, et al.
Publicado: (2023)

Evolution of DIMBOA-Glc O-Methyltransferases from Flavonoid O-Methyltransferases in the Grasses
por: Förster, Christiane, et al.
Publicado: (2022)

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
por: Miyara, Makoto, et al.
Publicado: (2016)

RNA methyltransferase METTL16: Targets and function
por: Satterwhite, Emily R., et al.
Publicado: (2021)

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase
por: Zhang, Jianyu, et al.
Publicado: (2016)

COrona-rap
por: van Hogendorp, Sophie
Publicado: (2020)

Rapping Mania
Publicado: (1853)

Spiritual Rappings
Publicado: (1853)

Rapping Mania
Publicado: (1853)

The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow
por: Zhang, Yun-Peng, et al.
Publicado: (2017)

METTL16, Methyltransferase-Like Protein 16: Current Insights into Structure and Function
por: Ruszkowska, Agnieszka
Publicado: (2021)

TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage
por: Soo Lee, Nam, et al.
Publicado: (2016)

Structural insights into the RNA methyltransferase domain of METTL16
por: Ruszkowska, Agnieszka, et al.
Publicado: (2018)

Rap1 and Rap2 Antagonistically Control Endothelial Barrier Resistance
por: Pannekoek, Willem-Jan, et al.
Publicado: (2013)

Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis
por: Zhou, Jian-Min, et al.
Publicado: (2010)

Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)
por: Mandrioli, Jessica, et al.
Publicado: (2018)

Real-world five-year outcomes of FlexyRap(®) cobalt-chromium rapamycin-eluting stents with biodegradable polymer in patients with de-novo coronary artery disease
por: Garg, Nitish, et al.
Publicado: (2023)

Large Hadron rap
Publicado: (2008)

Particle physics rap
Publicado: (2008)

Particle physics rap
Publicado: (2008)

Rap1b but not Rap1a in the forebrain is required for learned fear
por: Chen, Wen-Bing, et al.
Publicado: (2020)

Opposite functions of RapA and RapC in cell adhesion and migration in Dictyostelium
por: Jeon, Jihyeon, et al.
Publicado: (2021)

Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m(7)G methyltransferases
por: Husain, Nilofer, et al.
Publicado: (2010)

Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP
por: Jensen, Jan K., et al.
Publicado: (2009)

Cientistas criam rap para explicar o Grande Colisor de Hádrons
Publicado: (2008)

The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues
por: Scrima, Andrea, et al.
Publicado: (2008)

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2
por: Struck, Anna-Winona, et al.
Publicado: (2012)

The Enigmatic Conservation of a Rap1 Binding Site in the Saccharomyces cerevisiae HMR-E Silencer
por: Teytelman, Leonid, et al.
Publicado: (2012)

Identification of preferential target sites for human DNA methyltransferases
por: Choi, Si Ho, et al.
Publicado: (2011)

Site-specific RNA methylation by a methyltransferase ribozyme
por: Scheitl, Carolin P. M., et al.
Publicado: (2020)

Physics geeks go rapping
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_c25jg93ob3hvjgqskh4ru6fbid