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The BCL-2 arbiters of apoptosis and their growing role as cancer targets
Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven development of a new class of cancer drugs th...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729526/ https://www.ncbi.nlm.nih.gov/pubmed/29099483 http://dx.doi.org/10.1038/cdd.2017.161 |