Cargando…

Dual inhibitors of hepatitis C virus and hepatocellular carcinoma: design, synthesis and docking studies

AIM: Simultaneous inhibition of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) may enhance anti-HCV effects and reduce resistance and side effects. RESULTS/METHODOLOGY: Novel hybrid derivatives were designed and synthesized to exhibit dual activity against HCV and its associated major co...

Descripción completa

Detalles Bibliográficos
Autores principales:	El-Miligy, Mostafa MM, Rida, Samia M, Ashour, Fawzia A, Badr, Mona H, El-Bassiony, Ehab M, El-Demellawy, Maha A, Omar, Ashraf M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Future Science Ltd 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729604/ https://www.ncbi.nlm.nih.gov/pubmed/29255624 http://dx.doi.org/10.4155/fsoa-2017-0075

Ejemplares similares

Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors
por: El-Miligy, Mostafa M. M., et al.
Publicado: (2022)

PI3K/Akt-Independent NOS/HO Activation Accounts for the Facilitatory Effect of Nicotine on Acetylcholine Renal Vasodilations: Modulation by Ovarian Hormones
por: Gohar, Eman Y., et al.
Publicado: (2014)

Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme
por: El-Dershaby, Nada H., et al.
Publicado: (2022)

Production of monoclonal antibody, Anti-CD3 by hybridoma cells cultivated in Basket Spinner under free and immobilized conditions
por: Elsayed, Elsayed A, et al.
Publicado: (2013)

Magnetite Nanoparticles Inhibit Tumor Growth and Upregulate the Expression of P53/P16 in Ehrlich Solid Carcinoma Bearing Mice
por: Bassiony, Heba, et al.
Publicado: (2014)

Antibacterial activity of Centaurea pumilio L. root and aerial part extracts against some multidrug resistant bacteria
por: Naeim, Huda, et al.
Publicado: (2020)

Enhancing Ezetimibe Anticancer Activity Through Development of Drug Nano-Micelles Formulations: A Promising Strategy Supported by Molecular Docking
por: Ahmed, Tarek A, et al.
Publicado: (2023)

Changes in composition of colostrum of Egyptian buffaloes and Holstein cows
por: Abd El -Fattah, Alaa M, et al.
Publicado: (2012)

Commercial Seaweed Liquid Extract as Strawberry Biostimulants and Bioethanol Production
por: Ashour, Mohamed, et al.
Publicado: (2022)

In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects
por: Abd El-Wahab, Abeer E, et al.
Publicado: (2013)

Ipriflavone and Ipriflavone loaded albumin nanoparticles reverse lipopolysaccharide induced neuroinflammation in rats
por: Yassa, Nashwa W., et al.
Publicado: (2020)

Larvicidal, Biological and Genotoxic Effects, and Temperature-Toxicity Relationship of Some Leaf Extracts of Nerium oleander (Apocynaceae) on Culex pipiens (Diptera: Culicidae)
por: El-Sayed, Shaurub H, et al.
Publicado: (2015)

Characterization, in-silico, and in-vitro study of a new steroid derivative from Ophiocoma dentata as a potential treatment for COVID-19
por: Abd El Hafez, Mohamed S. M., et al.
Publicado: (2022)

Tissue Distribution, Histopathological and Genotoxic Effects of Magnetite Nanoparticles on Ehrlich Solid Carcinoma
por: Bassiony, Heba, et al.
Publicado: (2022)

Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions
por: Zekri, Abdel-Rahman N, et al.
Publicado: (2018)

Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4
por: Shaker, Olfat, et al.
Publicado: (2013)

Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity
por: Ashmawy, Naglaa S., et al.
Publicado: (2016)

Investigation of the Immunomodulatory effect of Berberis vulgaris on core-pulsed dendritic cell vaccine
por: Ghareeb, Doaa A., et al.
Publicado: (2016)

Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities
por: El-Miligy, Mostafa M. M., et al.
Publicado: (2023)

Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs
por: El-Dershaby, Nada H., et al.
Publicado: (2022)

Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFR(wt) and aromatase (CYP19A) inhibitors; a study supported by molecular docking
por: Hamed, Ashraf N. E., et al.
Publicado: (2022)

Hydroxychloroquine-Loaded Chitosan Nanoparticles Induce Anticancer Activity in A549 Lung Cancer Cells: Design, BSA Binding, Molecular Docking, Mechanistic, and Biological Evaluation
por: Elshami, Fawzia I., et al.
Publicado: (2023)

Impact of malathion toxicity on the oxidative stress parameters of the black soldier fly Hermetia illucens (Linnaeus, 1758) (Diptera: Stratiomyidae)
por: Abdelfattah, Eman Alaaeldin, et al.
Publicado: (2022)

Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
por: El-Abd, Azhar O., et al.
Publicado: (2022)

Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia
por: El-Nashar, Heba A. S., et al.
Publicado: (2023)

Design, Synthesis and Molecular Docking of Novel Acetophenone-1,2,3-Triazoles Containing Compounds as Potent Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors
por: Albelwi, Fawzia Faleh, et al.
Publicado: (2022)

Phytochemical profile, enzyme inhibition activity and molecular docking analysis of Feijoa sellowiana O. Berg
por: Saber, Fatema R., et al.
Publicado: (2021)

DNA Binding and Cleavage, Stopped-Flow Kinetic, Mechanistic, and Molecular Docking Studies of Cationic Ruthenium(II) Nitrosyl Complexes Containing “NS(4)” Core
por: Shereef, Hadeer A., et al.
Publicado: (2023)

Seroprevalence of Hepatitis A, B and C Among a Sample of Refugees in Egypt: An Exploratory Survey
por: El-Ghitany, Engy Mohamed, et al.
Publicado: (2022)

Preparation, physicochemical characterization, and bioactivity evaluation of berberine-entrapped albumin nanoparticles
por: Younis, Fatema A., et al.
Publicado: (2022)

Bioinformatics analysis of multi-epitope peptide vaccines against Hepatitis C virus: a molecular docking study
por: Muhammad, Ashraf M., et al.
Publicado: (2023)

The Apoptotic Effect of Trichinella spiralis Infection Against Experimentally Induced Hepatocellular Carcinoma
por: Elhasawy, Fawzya A, et al.
Publicado: (2021)

EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones
por: Musa, Arafa, et al.
Publicado: (2022)

Review of Current Applications of Immunohistochemistry in Pediatric Nonneoplastic Gastrointestinal, Hepatobiliary, and Pancreatic Lesions
por: de Nanassy, Joseph, et al.
Publicado: (2017)

Novel Hybrid 1,2,4- and 1,2,3-Triazoles Targeting Mycobacterium Tuberculosis Enoyl Acyl Carrier Protein Reductase (InhA): Design, Synthesis, and Molecular Docking
por: El Sawy, Maged A., et al.
Publicado: (2022)

The Role of LINC01564, RAMS11, CBX4 and TOP2A in Hepatocellular Carcinoma
por: Badr, Eman A. E., et al.
Publicado: (2022)

Simple dihydropyridine-based colorimetric chemosensors for heavy metal ion detection, biological evaluation, molecular docking, and ADMET profiling
por: Hamada, Wafaa M., et al.
Publicado: (2023)

Dual-ligated metal organic framework as novel multifunctional nanovehicle for targeted drug delivery for hepatic cancer treatment
por: Fytory, Mostafa, et al.
Publicado: (2021)

Synthesis, structural characterization, antioxidant, cytotoxic activities and docking studies of schiff base Cu(II) complexes
por: Rezk, Ghada N., et al.
Publicado: (2023)

Value of α-smooth muscle actin and glial fibrillary acidic protein in predicting early hepatic fibrosis in chronic hepatitis C virus infection
por: Zakaria, Sohier, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_u91koblv1qtjfhefut4ij8j5in