Cargando…

Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, with a low 5-year overall survival rate. In previous studies, we and others have found that 9p21.3 was the most frequently deleted region in ESCC. The MTAP gene, which is located close to CDKN2A/B in 9p21.3, encodes met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Xiao-Yu, Liu, Zou, Shang, Li, Cai, Hong-Qing, Zhang, Yu, Cai, Yan, Xu, Xin, Hao, Jia-Jie, Wang, Ming-Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729838/ https://www.ncbi.nlm.nih.gov/pubmed/29270023 http://dx.doi.org/10.2147/OTT.S151953

Ejemplares similares

Downregulation of MTAP promotes Tumor Growth and Metastasis by regulating ODC Activity in Breast Cancer
por: Zhang, Ying, et al.
Publicado: (2022)

Deletion of Dinucleotide Repeat (Δ14 Allele) in the Methylthioadenosine Phosphorylase (MTAP) Promoter and the Allelotype of MTAP Promoter in the Japanese Population
por: Kadariya, Yuwaraj, et al.
Publicado: (2002)

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine
por: Barekatain, Yasaman, et al.
Publicado: (2021)

Magnetic-Driven Hydrogel Microrobots Selectively Enhance Synthetic Lethality in MTAP-Deleted Osteosarcoma
por: Mu, Haoran, et al.
Publicado: (2022)

Deletions of CDKN2A and MTAP Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma
por: Vrugt, Bart, et al.
Publicado: (2023)

Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells
por: Sanderson, Sydney M., et al.
Publicado: (2019)

Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance
por: Li, Chien-Feng, et al.
Publicado: (2014)

A Panel of Overexpressed Proteins for Prognosis in Esophageal Squamous Cell Carcinoma
por: Shang, Li, et al.
Publicado: (2014)

MTAP: The Motif Tool Assessment Platform
por: Quest, Daniel, et al.
Publicado: (2008)

Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts
por: Xie, Huaping, et al.
Publicado: (2016)

PRMT5 silencing selectively affects MTAP‐deleted mesothelioma: In vitro evidence of a novel promising approach
por: Barbarino, Marcella, et al.
Publicado: (2020)

RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma
por: Zhang, Lan, et al.
Publicado: (2015)

Elevated serum eotaxin and IP‐10 levels as potential biomarkers for the detection of esophageal squamous cell carcinoma
por: Chang, Chen, et al.
Publicado: (2021)

High Expression of Citron Kinase Contributes to the Development of Esophageal Squamous Cell Carcinoma
por: Lu, Wenfeng, et al.
Publicado: (2021)

MTAP loss: a possible therapeutic approach for glioblastoma
por: Patro, C. Pawan K., et al.
Publicado: (2022)

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
por: Engstrom, Lars D., et al.
Publicado: (2023)

KIAA1522 overexpression promotes tumorigenicity and metastasis of esophageal cancer cells through potentiating the ERK activity
por: Xie, Zhi-Hui, et al.
Publicado: (2017)

Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice
por: Kadariya, Yuwaraj, et al.
Publicado: (2013)

Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP‐deficient lung cancer
por: Chang, Wen‐Hsin, et al.
Publicado: (2022)

Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
por: Li, Fang, et al.
Publicado: (2018)

Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines
por: de Oliveira, Sarah Franco Vieira, et al.
Publicado: (2016)

Transition state analogue of MTAP extends lifespan of APC(Min/+) mice
por: Firestone, Ross S., et al.
Publicado: (2021)

MTAP-related increased erythroblast proliferation as a mechanism of polycythaemia vera
por: Tipgomut, Chartsiam, et al.
Publicado: (2021)

The potential and challenges of targeting MTAP-negative cancers beyond synthetic lethality
por: Bray, Chandler, et al.
Publicado: (2023)

HGG-02. METABOLIC TARGETING OF HIGH-GRADE GLIOMAS WITH MTAP LOSS
por: Subramaniam, Bavani, et al.
Publicado: (2023)

Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells
por: Wang, Juan-Juan, et al.
Publicado: (2023)

Downregulation of Ubiquitin Inhibits the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma
por: Gao, Yi, et al.
Publicado: (2020)

Targeting the insulin-like growth factor-1 receptor in MTAP-deficient renal cell carcinoma
por: Xu, Jihao, et al.
Publicado: (2019)

RIOK1 kinase activity is required for cell survival irrespective of MTAP status
por: Hörmann, Alexandra, et al.
Publicado: (2018)

Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression
por: Busacca, Sara, et al.
Publicado: (2021)

MicroRNA-218 Is Deleted and Downregulated in Lung Squamous Cell Carcinoma
por: Davidson, Morgan R., et al.
Publicado: (2010)

Peroral endoscopic myotomy for esophageal motility disorders
por: Feng, Jie, et al.
Publicado: (2019)

Downregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells
por: Luo, Wenguang, et al.
Publicado: (2019)

DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma
por: Zhou, Y, et al.
Publicado: (2018)

MicroRNA-212 facilitates the motility and invasiveness of esophageal squamous carcinoma cells
por: Chen, Zhi, et al.
Publicado: (2019)

Downregulation of HOXA13 sensitizes human esophageal squamous cell carcinoma to chemotherapy
por: Shi, Qi, et al.
Publicado: (2018)

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization
por: Hansen, Landon J., et al.
Publicado: (2022)

m(6)A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression
por: Xiao, Dong, et al.
Publicado: (2021)

Chloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia
por: Liu, Shan-Wen, et al.
Publicado: (2017)

Eosinophilic esophagitis and esophageal motility changes
por: Surdea-Blaga, Teodora, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_j6kpc133kbnn6215adf78a9emc