Bitopic fluorescent antagonists of the A(2A) adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners

A pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine antagonist of the A(2A) adenosine receptor (AR) was functionalized as amine congeners, fluorescent conjugates and a sulfonate, and the A(2A)AR binding modes were predicted computationally. The optimal n-butyl spacer was incorporated into the f...

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Detalles Bibliográficos
Autores principales: Duroux, Romain, Ciancetta, Antonella, Mannes, Philip, Yu, Jinha, Boyapati, Shireesha, Gizewski, Elizabeth, Yous, Said, Ciruela, Francisco, Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729930/
https://www.ncbi.nlm.nih.gov/pubmed/29250307
http://dx.doi.org/10.1039/c7md00247e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729930/
https://www.ncbi.nlm.nih.gov/pubmed/29250307
http://dx.doi.org/10.1039/c7md00247e

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