Cargando…
Bitopic fluorescent antagonists of the A(2A) adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners
A pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine antagonist of the A(2A) adenosine receptor (AR) was functionalized as amine congeners, fluorescent conjugates and a sulfonate, and the A(2A)AR binding modes were predicted computationally. The optimal n-butyl spacer was incorporated into the f...
Autores principales: | Duroux, Romain, Ciancetta, Antonella, Mannes, Philip, Yu, Jinha, Boyapati, Shireesha, Gizewski, Elizabeth, Yous, Said, Ciruela, Francisco, Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729930/ https://www.ncbi.nlm.nih.gov/pubmed/29250307 http://dx.doi.org/10.1039/c7md00247e |
Ejemplares similares
-
Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines
por: Atta, Kamal F.M.
Publicado: (2011) -
Synthesis and Antimicrobial Activity of Some New Pyrazole, Fused Pyrazolo[3,4-d]-pyrimidine and Pyrazolo[4,3-e][1,2,4]-triazolo[1,5-c]pyrimidine Derivatives
por: Abunada, Nada M., et al.
Publicado: (2008) -
The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives
por: Federico, Stephanie, et al.
Publicado: (2015) -
Discovery of pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives as novel CDK2 inhibitors: synthesis, biological and molecular modeling investigations
por: Nassar, Ibrahim F., et al.
Publicado: (2022) -
Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity
por: Mandour, Asmaa A., et al.
Publicado: (2022)